XBI vs. INNO ETF Comparison

Comparison of SPDR S&P Biotech ETF (XBI) to Harbor Disruptive Innovation ETF (INNO)

XBI

SPDR S&P Biotech ETF

XBI Description

The investment seeks to provide investment results that, before fees and expenses, correspond generally to the total return performance of an index derived from the biotechnology segment of a U.S. total market composite index. In seeking to track the performance of the S&P Biotechnology Select Industry Index (the "index"), the fund employs a replication strategy. It generally invests substantially all, but at least 80%, of its total assets in the securities comprising the index. The index represents the biotechnology industry group of the S&P Total Market Index ("S&P TMI"). The fund is non-diversified.

Grade (RS Rating)

Last Trade

$96.24

Average Daily Volume

8,531,296

Number of Holdings ^*

128

* may have additional holdings in another (foreign) market

INNO

Harbor Disruptive Innovation ETF

INNO Description

INNO invests in stocks of any size with growth potential linked to disruptive innovation. The fund aims to achieve enhanced risk-adjusted investment outcome by utilizing an active multi-manager approach in which the advisor allocates assets among subadvisors. Each subadvisor represents a strategy that targets associated disruptive companies in technology, advanced therapies, analog-to-digital transition, structural changes and secular trends, and products or services with large demand. The advisor determines and adjusts allocations based on qualitative and quantitative assessments of each strategy, as well as in combination. The fund may invest up to 25% in foreign markets, including developing countries. INNO utilizes the same investment strategy and portfolio management team as its mutual fund counterpart, Harbor Disruptive Innovation Fund.

Grade (RS Rating)

Last Trade

$17.23

Average Daily Volume

29,808

Number of Holdings ^*

* may have additional holdings in another (foreign) market

Performance

Period	XBI	INNO
30 Days	-0.44%	8.00%
60 Days	-2.97%	8.03%
90 Days	-5.18%	10.18%
12 Months	32.40%	29.81%

3 Overlapping Holdings

Symbol	Grade	Weight in XBI	Weight in INNO	Overlap
MRNA	F	1.57%	0.39%	0.39%
PCVX	D	0.9%	0.25%	0.25%
RCKT	F	0.28%	0.33%	0.28%

XBI Overweight 125 Positions Relative to INNO

Symbol	Grade	Weight
NTRA	B	3.3%
INCY	C	3.29%
GILD	C	2.9%
UTHR	C	2.88%
NBIX	C	2.62%
VRTX	F	2.62%
INSM	C	2.43%
ALNY	D	2.38%
ABBV	D	2.33%
AMGN	D	2.28%
SRPT	D	2.28%
BIIB	F	2.19%
MDGL	B	2.17%
EXAS	D	2.05%
VKTX	F	2.0%
BMRN	D	1.98%
REGN	F	1.8%
CYTK	F	1.79%
BPMC	C	1.69%
CRSP	D	1.63%
TGTX	B	1.62%
RVMD	C	1.46%
RNA	D	1.32%
KRYS	B	1.29%
HALO	F	1.27%
EXEL	B	1.23%
ADMA	B	1.23%
ROIV	C	1.18%
ALKS	B	1.13%
IONS	F	1.08%
TWST	D	0.93%
IOVA	F	0.88%
BBIO	F	0.87%
APLS	D	0.86%
GERN	D	0.86%
CRNX	C	0.84%
ACLX	C	0.79%
DYN	F	0.78%
ACAD	D	0.78%
SWTX	C	0.77%
AGIO	C	0.76%
BEAM	D	0.72%
RARE	D	0.69%
RXRX	F	0.66%
PTCT	B	0.64%
FOLD	F	0.63%
IMVT	F	0.62%
RYTM	C	0.61%
NUVL	D	0.6%
NTLA	F	0.58%
PTGX	C	0.58%
VERA	B	0.57%
MIRM	B	0.57%
ARWR	F	0.54%
IDYA	F	0.53%
VCYT	B	0.53%
JANX	C	0.51%
SRRK	B	0.49%
DVAX	C	0.49%
NVAX	F	0.47%
ARDX	F	0.47%
VCEL	B	0.46%
DNLI	D	0.46%
KYMR	D	0.45%
SNDX	F	0.44%
AKRO	B	0.43%
CGON	F	0.42%
ARQT	C	0.42%
BCRX	D	0.42%
CPRX	C	0.41%
KROS	D	0.36%
IRON	B	0.34%
MNKD	C	0.34%
CLDX	F	0.34%
NRIX	D	0.33%
SMMT	D	0.33%
VRDN	D	0.3%
DAWN	F	0.28%
MYGN	F	0.27%
IRWD	F	0.26%
TVTX	B	0.26%
CGEM	F	0.25%
CDNA	D	0.24%
KURA	F	0.24%
XNCR	B	0.24%
APLT	B	0.22%
CDMO	B	0.22%
RCUS	F	0.2%
VIR	D	0.2%
EBS	C	0.2%
REPL	B	0.18%
HUMA	F	0.18%
ALT	C	0.18%
SPRY	D	0.18%
AVXL	B	0.17%
ARCT	F	0.17%
ANNX	F	0.16%
STOK	F	0.16%
ETNB	C	0.16%
MDXG	B	0.16%
COGT	D	0.16%
VERV	F	0.15%
RLAY	F	0.14%
OLMA	F	0.13%
IMNM	F	0.13%
PRTA	F	0.13%
OCGN	F	0.12%
ANAB	F	0.12%
FDMT	F	0.12%
SANA	F	0.12%
RGNX	F	0.12%
ALLO	F	0.11%
CELC	F	0.11%
SAGE	F	0.11%
CCCC	F	0.1%
ERAS	C	0.1%
ORIC	F	0.09%
FATE	F	0.08%
SVRA	D	0.08%
ABUS	D	0.07%
KALV	D	0.07%
SCLX	F	0.06%
YMAB	F	0.06%
ITOS	F	0.06%
ALEC	F	0.04%

XBI Underweight 65 Positions Relative to INNO

Symbol	Grade	Weight
NVDA	C	-4.35%
SHOP	B	-3.91%
NOW	A	-3.73%
GOOG	C	-3.38%
CDNS	B	-3.13%
AMZN	C	-2.97%
FI	A	-2.94%
MELI	D	-2.85%
PGR	A	-2.82%
DASH	A	-2.82%
URI	B	-2.81%
LIN	D	-2.53%
LRCX	F	-2.42%
DHR	F	-2.42%
TXN	C	-2.3%
TEAM	A	-2.23%
IOT	A	-2.16%
TOST	B	-2.03%
META	D	-2.01%
GOOGL	C	-1.96%
MSFT	F	-1.92%
ASND	D	-1.55%
CMG	B	-1.51%
DDOG	A	-1.38%
AMD	F	-1.36%
TSM	B	-1.33%
PCOR	B	-1.2%
CGNX	C	-1.2%
NET	B	-1.17%
NFLX	A	-1.14%
HUBS	A	-1.11%
GTLS	B	-1.09%
CRM	B	-0.9%
S	B	-0.84%
SAP	B	-0.84%
SE	B	-0.83%
MEDP	D	-0.82%
ORCL	B	-0.81%
PANW	C	-0.8%
MNDY	C	-0.8%
ZS	C	-0.79%
MTSI	B	-0.77%
GEV	B	-0.67%
SQ	B	-0.65%
ROKU	D	-0.65%
LSCC	D	-0.64%
NU	C	-0.63%
DT	C	-0.62%
MDB	C	-0.62%
AMAT	F	-0.61%
PODD	C	-0.58%
GLBE	B	-0.57%
LLY	F	-0.54%
OKTA	C	-0.53%
DKNG	B	-0.5%
ICLR	D	-0.46%
TSLA	B	-0.46%
CRWD	B	-0.45%
SAIA	B	-0.45%
SNOW	C	-0.43%
LEGN	F	-0.41%
TDG	D	-0.33%
DXCM	D	-0.32%
CHKP	D	-0.32%
BCYC	F	-0.16%