Southwest Florida is the region along the southwest Gulf coast of the U.S. state of Florida. The area is known for its beaches, subtropical landscape, and winter resort economy.Definitions of the region vary, though its boundaries are generally considered to put it south of the Tampa Bay area, west of Lake Okeechobee, and mostly north of the Everglades and to include Manatee, Sarasota, Charlotte, Lee, and Collier counties. For some purposes, the inland counties of DeSoto, Glades, and Hendry, and the thinly populated mainland section of Monroe County, south of Collier, are also included.The region includes four metropolitan areas: the North Port-Bradenton-Sarasota MSA, the Cape Coral-Fort Myers MSA, the Naples-Marco Island MSA, and the Punta Gorda MSA. The most populous county in the region is Lee County (661,000 population), and the region's largest city is Cape Coral with a population of 165,831 as of 2013.