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    Orphan Drug ETF List

    ETFs which hold one or more stocks tagged as: Orphan Drug

    Symbol Grade Name Weight
    PBE D PowerShares Dynamic Biotech & Genome 7.37
    FBT D First Trust Amex Biotech Index Fund 6.63
    WDNA D WisdomTree BioRevolution Fund 4.66
    IBB D iShares Nasdaq Biotechnology Index Fund 4.43
    ARKG F ARK Genomic Revolution Multi-Sector ETF 4.31
    BTEC D Principal Healthcare Innovators Index ETF 3.97
    BBP D BioShares Biotechnology Products Fund 3.49
    HELX D Franklin Genomic Advancements ETF 3.32
    LABD B Direxion Daily S&P Biotech Bear 3X Shares 3.27
    XBI D SPDR S&P Biotech ETF 3.2
    HRTS D Tema Cardiovascular and Metabolic ETF 2.93
    BBH D Market Vectors Biotech ETF 2.72
    LABU F Direxion Daily S&P Biotech Bull 3X Shares 2.27
    BBC D Virtus LifeSci Biotech Clinical Trials ETF 2.15
    IBBQ D Invesco Nasdaq Biotechnology ETF 2.07
    NUMG C NuShares ESG Mid-Cap Growth ETF 1.55
    BIB D ProShares Ultra Nasdaq Biotechnology 1.54
    BIS A ProShares UltraShort Nasdaq Biotechnology 1.34
    CNCR D Loncar Cancer Immunotherapy ETF 1.3
    GURU C Global X Top Guru Holdings Index ETF 1.3
    ETHO C Etho Climate Leadership U.S. ETF 1.04
    VBK C Vanguard Small-Cap Growth ETF 1.01
    ISCG C iShares Morningstar Small-Cap Growth ETF 0.95
    TMFX C Motley Fool Next Index ETF 0.95
    SBIO D ALPS Medical Breakthroughs ETF 0.95
    PEXL C Pacer US Export Leaders ETF 0.87
    IVOG C Vanguard S&P Mid-Cap 400 Growth ETF 0.87
    IJK C iShares S&P Mid-Cap 400 Growth ETF 0.86
    MDYG C SPDR S&P 400 Mid Cap Growth ETF 0.86
    ILDR C First Trust Innovation Leaders ETF 0.83
    QQJG C Invesco ESG NASDAQ Next Gen 100 ETF 0.81
    IWO C iShares Russell 2000 Growth ETF 0.8
    GDOC C Goldman Sachs Future Health Care Equity ETF 0.79
    VTWG C Vanguard Russell 2000 Growth ETF 0.77
    FRTY C Alger Mid Cap 40 ETF 0.68
    BBMC C JPMorgan BetaBuilders U.S. Mid Cap Equity ETF 0.67
    BKMC C BNY Mellon US Mid Cap Core Equity ETF 0.66
    VIOG C Vanguard S&P Small-Cap 600 Growth ETF 0.63
    PWS C Pacer WealthShield ETF 0.62
    QQQJ C Invesco NASDAQ Next Gen 100 ETF 0.62
    XPH D SPDR S&P Pharmaceuticals ETF 0.61
    MDY C SPDR MidCap Trust Series I 0.6
    IVOO C Vanguard S&P Mid-Cap 400 ETF 0.6
    SMDY B Syntax Stratified MidCap ETF 0.6
    PTMC C Pacer Trendpilot 450 ETF 0.59
    IJH C iShares Core S&P Mid-Cap ETF 0.59
    SPMD C SPDR Portfolio Mid Cap ETF 0.59
    ISCB C iShares Morningstar Small-Cap ETF 0.57
    MIDE C Xtrackers S&P MidCap 400 ESG ETF 0.55
    FFLG C Fidelity Fundamental Large Cap Growth ETF 0.55
    MMSC C First Trust Multi-Manager Small 0.53
    SMLF C iShares FactorSelect MSCI USA Small-Cap ETF 0.53
    PILL F Direxion Daily Pharmaceutical & Medical Bull 3X Shares ETF 0.5
    SMMV B iShares MSCI USA Small-Cap Min Vol Factor ETF 0.49
    FTXH D First Trust Nasdaq Pharmaceuticals ETF 0.48
    SCHA C Schwab U.S. Small-Cap ETF 0.47
    JHSC C John Hancock Multifactor Small Cap ETF 0.46
    MVV C ProShares Ultra MidCap400 0.46
    HART B IQ Healthy Hearts ETF 0.45
    CACG C ClearBridge All Cap Growth ETF 0.45
    FFSM C Fidelity Fundamental Small-Mid Cap ETF 0.45
    VB C Vanguard Small-Cap ETF 0.44
    IWM C iShares Russell 2000 ETF 0.43
    XT D iShares Exponential Technologies ETF 0.42
    FSMD C Fidelity Small-Mid Factor ETF 0.41
    NULG C NuShares ESG Large-Cap Growth ETF 0.41
    VHT C Vanguard Health Care ETF 0.4
    VTWO C Vanguard Russell 2000 ETF 0.4
    FHLC C Fidelity MSCI Health Care Index ETF 0.39
    VXF C Vanguard Extended Market ETF 0.39
    NUSC C NuShares ESG Small-Cap ETF 0.39
    ISMD C Inspire Small/Mid Cap Impact ETF 0.39
    UMDD C UltraPro MidCap400 0.38
    XJH B iShares ESG Screened S&P Mid-Cap ETF 0.37
    PSC C Principal U.S. Small Cap Index ETF 0.37
    FLDZ B RiverNorth Volition America Patriot ETF 0.37
    QVMM C Invesco S&P MidCap 400 QVM Multi-factor ETF 0.36
    SCHM C Schwab U.S. Mid Cap ETF 0.35
    RYLD B Global X Russell 2000 Covered Call ETF 0.34
    UWM C ProShares Ultra Russell2000 0.34
    FTLS C First Trust Long/Short Equity 0.31
    URTY C ProShares UltraPro Russell2000 0.3
    IJJ C iShares S&P Mid-Cap 400 Value ETF 0.3
    FNY C First Trust Mid Cap Growth AlphaDEX 0.3
    IYH C iShares U.S. Healthcare ETF 0.29
    IVOV C Vanguard S&P Mid-Cap 400 Value ETF 0.29
    IWP C iShares Russell Midcap Growth ETF 0.29
    MDYV C SPDR S&P 400 Mid Cap Value ETF (based on S&P MidCap 400 Value Index 0.28
    NSCS B Nuveen Small Cap Select ETF 0.28
    IHE D iShares U.S. Pharmaceutical ETF 0.28
    FPXE C First Trust IPOX Europe Equity Opportunities ETF 0.26
    SMMD C iShares Russell 2500 ETF 0.25
    TZA C Direxion Small Cap Bear 3X Shares 0.25
    SFYX C SoFi Next 500 ETF 0.25
    ESML C iShares MSCI USA Small-Cap ESG Optimized ETF 0.25
    ISCV C iShares Morningstar Small-Cap Value ETF 0.21
    JHMM C John Hancock Multifactor Mid Cap ETF 0.2
    TPLE B Timothy Plan US Large/Mid Cap Core Enhanced ETF 0.19
    TPLC C Timothy Plan US Large Cap Core ETF 0.19
    PRFZ C PowerShares FTSE RAFI US 1500 Small-Mid Portfolio 0.17
    BKSE C BNY Mellon US Small Cap Core Equity ETF 0.16
    FTQI C First Trust Low Beta Income ETF 0.15
    EQAL B PowerShares Russell 1000 Equal Weight Portfolio 0.15
    IWR B iShares Russell Mid-Cap ETF 0.14
    GSSC C Goldman Sachs ActiveBeta U.S. Small Cap Equity ETF 0.13
    EUSA B iShares MSCI USA Index Fund 0.13
    ONEQ C Fidelity Nasdaq Composite Index Tracking Stock 0.12
    IWC C iShares Microcap ETF 0.11
    FAD C First Trust MuFirst Trust Multi CG AlphaDEX 0.1
    AVSC C Avantis U.S. Small Cap Equity ETF 0.1
    CFA B Compass EMP US 500 Volatility Weighted Index ETF 0.09
    CFO B Compass EMP US 500 Enhanced Volatility Weighted Index ETF 0.09
    SUSA B iShares MSCI USA ESG Select ETF 0.09
    JMEE C JPMorgan Market Expansion Enhanced Equity ETF 0.09
    HKND B Humankind US Stock ETF 0.09
    PABU C iShares Paris-Aligned Climate MSCI USA ETF 0.09
    IWS B iShares Russell Mid-cap Value ETF 0.08
    EGUS C iShares ESG Aware MSCI USA Growth ETF 0.08
    KOMP C SPDR Kensho New Economies Composite ETF 0.08
    ESGV C Vanguard ESG U.S. Stock ETF 0.08
    ESGU B iShares MSCI USA ESG Optimized ETF 0.08
    TILT B FlexShares Mornigstar US Market Factors Tilt Index Fund ETF 0.07
    AVDE B Avantis International Equity ETF 0.07
    JSTC C Adasina Social Justice All Cap Global ETF 0.07
    EZM C WisdomTree MidCap Earnings Fund 0.07
    FNX C First Trust Mid Cap Core AlphaDEX 0.07
    JCTR B JPMorgan Carbon Transition U.S. Equity ETF 0.06
    QRFT C QRAFT AI-Enhanced U.S. Large Cap ETF 0.06
    AVSD B Avantis Responsible International Equity ETF 0.06
    HDG B ProShares Hedge Replication ETF 0.06
    SCHB B Schwab U.S. Broad Market ETF 0.05
    ITOT B iShares Core S&P Total U.S. Stock Market ETF 0.05
    AVSU C Avantis Responsible U.S. Equity ETF 0.05
    IWN C iShares Russell 2000 Value ETF 0.05
    USXF C iShares ESG Advanced MSCI USA ETF 0.05
    DFAC B Dimensional U.S. Core Equity 2 ETF 0.05
    IWV B iShares Russell 3000 ETF 0.05
    SPTM B SPDR Portfolio Total Stock Market ETF 0.04
    MMTM C SPDR S&P 1500 Momentum Tilt ETF 0.04
    IWF C iShares Russell 1000 Growth ETF 0.04
    USSG C Xtrackers MSCI USA ESG Leaders Equity ETF 0.04
    SUSL C iShares ESG MSCI USA Leaders ETF 0.04
    VONG C Vanguard Russell 1000 Growth ETF 0.04
    FNDA C Schwab Fundamental U.S. Small Company Index ETF 0.04
    GUSA C Goldman Sachs MarketBeta U.S. 1000 Equity ETF 0.04
    SCHG C Schwab U.S. Large-Cap Growth ETF 0.04
    BBSC C JPMorgan BetaBuilders U.S. Small Cap Equity ETF 0.04
    IUSG C iShares Core U.S. Growth ETF 0.04
    VTWV C Vanguard Russell 2000 Value ETF 0.04
    AVUS B Avantis U.S. Equity ETF 0.03
    USCL B iShares Climate Conscious & Transition MSCI USA ETF 0.03
    VT B Vanguard Total World Stock Index ETF 0.03
    IYY B iShares Dow Jones U.S. ETF 0.03
    IWB B iShares Russell 1000 ETF 0.03
    SCHK B Schwab 1000 ETF 0.03
    VONV B Vanguard Russell 1000 Value ETF 0.03
    DFAU B Dimensional US Core Equity Market ETF 0.02
    IUSV B iShares Core U.S. Vaue ETF 0.02
    JMOM B JPMorgan U.S. Momentum Factor ETF 0.02
    ONEO C SPDR Russell 1000 Momentum Focus ETF 0.02
    PBUS B Invesco PureBeta MSCI USA ETF 0.02
    SCHX B Schwab U.S. Large-Cap ETF 0.02
    DFUV B Dimensional US Marketwide Value ETF 0.02
    RWK C RevenueShares Mid Cap 0.02
    JUST B Goldman Sachs JUST U.S. Large Cap Equity ETF 0.02
    DFUS B Dimensional U.S. Equity ETF 0.02
    IWD B iShares Russell 1000 Value ETF 0.02
    JHML B John Hancock Multifactor Large Cap ETF 0.02
    SPGM B SPDR Portfolio MSCI Global Stock Market ETF 0.01
    RECS C Columbia Research Enhanced Core ETF 0.01
    TSPA B T. Rowe Price U.S. Equity Research ETF 0.01
    TOK B iShares MSCI KLD 400 Social ETF 0.01
    KOKU B Xtrackers MSCI Kokusai Equity ETF 0.01
    ACWI B iShares MSCI ACWI Index Fund 0.01
    URTH B iShares MSCI World Index Fund 0.01
    DFAS C Dimensional U.S. Small Cap ETF 0.01
    VLU B SPDR S&P 1500 Value Tilt ETF 0.01
    DFAI B Dimensional International Core Equity Market ETF 0.01
    DEUS C Deutsche X-trackers Russell 1000 Enhanced Beta ETF 0.01
    DFIV A Dimensional International Value ETF 0.01
    MFUS B PIMCO RAFI Dynamic Multi-Factor U.S. Equity ETF 0.01
    FNDB B Schwab Fundamental U.S. Broad Market Index ETF 0.0
    QUS B SPDR MSCI USA Quality Mix ETF 0.0
    REVS B Columbia Research Enhanced Value ETF 0.0
    BTAL A QuantShares U.S. Market Neutral Anti Beta Fund ETF -0.35
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