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    Orphan Drug ETF List

    ETFs which hold one or more stocks tagged as: Orphan Drug

    Symbol Grade Name Weight
    FBT D First Trust Amex Biotech Index Fund 6.5
    HRTS D Tema Cardiovascular and Metabolic ETF 5.89
    WDNA D WisdomTree BioRevolution Fund 4.42
    ARKG F ARK Genomic Revolution Multi-Sector ETF 3.85
    XBI D SPDR S&P Biotech ETF 3.5
    BBC D Virtus LifeSci Biotech Clinical Trials ETF 3.21
    HELX D Franklin Genomic Advancements ETF 3.18
    FRTY A Alger Mid Cap 40 ETF 3.03
    MEDX F Horizon Kinetics Medical ETF 2.78
    PBE D PowerShares Dynamic Biotech & Genome 2.76
    MNTL D Tema Neuroscience and Mental Health ETF 2.66
    BBP C BioShares Biotechnology Products Fund 2.62
    BKIV A BNY Mellon Innovators ETF 2.59
    FMED D Fidelity Disruptive Medicine ETF 2.53
    SBIO C ALPS Medical Breakthroughs ETF 2.48
    BMED D BlackRock Future Health ETF 2.47
    LABU F Direxion Daily S&P Biotech Bull 3X Shares 2.32
    IBB D iShares Nasdaq Biotechnology Index Fund 2.22
    BBH D Market Vectors Biotech ETF 2.19
    SOVF B Sovereign's Capital Flourish Fund 1.95
    CANC D Tema Oncology ETF 1.84
    IBBQ D Invesco Nasdaq Biotechnology ETF 1.78
    CSMD B Congress SMid Growth ETF 1.44
    BIB F ProShares Ultra Nasdaq Biotechnology 1.35
    BIS B ProShares UltraShort Nasdaq Biotechnology 1.34
    GURU B Global X Top Guru Holdings Index ETF 1.18
    CNCR F Loncar Cancer Immunotherapy ETF 1.17
    PEXL C Pacer US Export Leaders ETF 0.95
    JHSC B John Hancock Multifactor Small Cap ETF 0.93
    ILDR B First Trust Innovation Leaders ETF 0.89
    XPH B SPDR S&P Pharmaceuticals ETF 0.87
    VBK A Vanguard Small-Cap Growth ETF 0.84
    QQQS C Invesco NASDAQ Future Gen 200 ETF 0.82
    MEDI D Harbor Health Care ETF 0.8
    ETHO B Etho Climate Leadership U.S. ETF 0.8
    TMFX A Motley Fool Next Index ETF 0.72
    SCDS B JPMorgan Fundamental Data Science Small Core ETF 0.7
    MIDE B Xtrackers S&P MidCap 400 ESG ETF 0.69
    MDYG B SPDR S&P 400 Mid Cap Growth ETF 0.67
    ISCG B iShares Morningstar Small-Cap Growth ETF 0.67
    IVOG B Vanguard S&P Mid-Cap 400 Growth ETF 0.65
    FPXE D First Trust IPOX Europe Equity Opportunities ETF 0.63
    QQJG B Invesco ESG NASDAQ Next Gen 100 ETF 0.61
    IJK B iShares S&P Mid-Cap 400 Growth ETF 0.6
    PILL C Direxion Daily Pharmaceutical & Medical Bull 3X Shares ETF 0.6
    BBMC A JPMorgan BetaBuilders U.S. Mid Cap Equity ETF 0.56
    SHRT F Gotham Short Strategies ETF 0.55
    GDOC D Goldman Sachs Future Health Care Equity ETF 0.55
    NXTI A Simplify Next Intangible Core Index ETF 0.54
    BKMC B BNY Mellon US Mid Cap Core Equity ETF 0.53
    XJH B iShares ESG Screened S&P Mid-Cap ETF 0.52
    HART D IQ Healthy Hearts ETF 0.51
    STXM B Strive Mid-Cap ETF 0.51
    QQQJ B Invesco NASDAQ Next Gen 100 ETF 0.5
    SMOT B VanEck MorVanEck Morningstar SMID Moat ETFningstar SMID Moat ETF 0.48
    FWD B AB Disruptors ETF 0.48
    IVOO B Vanguard S&P Mid-Cap 400 ETF 0.47
    IWN B iShares Russell 2000 Value ETF 0.46
    VTWV B Vanguard Russell 2000 Value ETF 0.46
    SMMV B iShares MSCI USA Small-Cap Min Vol Factor ETF 0.45
    MMSC B First Trust Multi-Manager Small 0.45
    PTMC B Pacer Trendpilot 450 ETF 0.45
    SPMD B SPDR Portfolio Mid Cap ETF 0.45
    MDY B SPDR MidCap Trust Series I 0.45
    ISCB B iShares Morningstar Small-Cap ETF 0.43
    IJH B iShares Core S&P Mid-Cap ETF 0.42
    FTXH D First Trust Nasdaq Pharmaceuticals ETF 0.41
    SCHA B Schwab U.S. Small-Cap ETF 0.4
    SCHM B Schwab U.S. Mid Cap ETF 0.39
    IWM B iShares Russell 2000 ETF 0.39
    ESML B iShares MSCI USA Small-Cap ESG Optimized ETF 0.38
    SMLF B iShares FactorSelect MSCI USA Small-Cap ETF 0.38
    TMSL B T. Rowe Price Exchange-Traded Funds, Inc. T. Rowe Price Small-Mid Cap ETF 0.38
    ISMD B Inspire Small/Mid Cap Impact ETF 0.37
    VB B Vanguard Small-Cap ETF 0.37
    FFSM B Fidelity Fundamental Small-Mid Cap ETF 0.37
    VTWO B Vanguard Russell 2000 ETF 0.36
    ITWO B ProShares Russell 2000 High Income ETF 0.35
    IQSM B IQ Candriam ESG U.S. Mid Cap Equity ETF 0.35
    RSSL B Global X Russell 2000 ETF 0.34
    FHLC D Fidelity MSCI Health Care Index ETF 0.33
    VHT D Vanguard Health Care ETF 0.33
    XT C iShares Exponential Technologies ETF 0.33
    MIDU B Direxion Mid Cap Bull 3X Shares 0.32
    VXF B Vanguard Extended Market ETF 0.31
    FESM B Fidelity Enhanced Small Cap ETF 0.31
    SFYX B SoFi Next 500 ETF 0.3
    VTWG B Vanguard Russell 2000 Growth ETF 0.29
    FLDZ A RiverNorth Volition America Patriot ETF 0.29
    NUSC B NuShares ESG Small-Cap ETF 0.28
    QVMM B Invesco S&P MidCap 400 QVM Multi-factor ETF 0.27
    UWM B ProShares Ultra Russell2000 0.26
    UMDD B UltraPro MidCap400 0.26
    MDYV B SPDR S&P 400 Mid Cap Value ETF (based on S&P MidCap 400 Value Index 0.24
    FENI D Fidelity Enhanced International ETF 0.24
    IJJ B iShares S&P Mid-Cap 400 Value ETF 0.24
    IVOV B Vanguard S&P Mid-Cap 400 Value ETF 0.23
    IYH D iShares U.S. Healthcare ETF 0.23
    IWC B iShares Microcap ETF 0.21
    FSMD B Fidelity Small-Mid Factor ETF 0.19
    IWP A iShares Russell Midcap Growth ETF 0.19
    ISCV B iShares Morningstar Small-Cap Value ETF 0.19
    RFLR D Innovator U.S. Small Cap Power Buffer ETF - September Innovator U.S. Small Cap Managed Floor ETF 0.18
    URTY C ProShares UltraPro Russell2000 0.18
    AVIE A Avantis Inflation Focused Equity ETF 0.16
    FFLG A Fidelity Fundamental Large Cap Growth ETF 0.16
    GSSC B Goldman Sachs ActiveBeta U.S. Small Cap Equity ETF 0.16
    JHMM B John Hancock Multifactor Mid Cap ETF 0.16
    EQAL A PowerShares Russell 1000 Equal Weight Portfolio 0.15
    FTQI A First Trust Low Beta Income ETF 0.15
    STXK B Strive 2000 ETF 0.15
    GWX D SPDR S&P International SmallCap ETF 0.14
    BKSE B BNY Mellon US Small Cap Core Equity ETF 0.14
    PRFZ B PowerShares FTSE RAFI US 1500 Small-Mid Portfolio 0.13
    CVMC B Calvert US Mid-Cap Core Responsible Index ETF 0.13
    FYC B First Trust Small Cap Growth AlphaDEX Fund 0.11
    IWR A iShares Russell Mid-Cap ETF 0.1
    ONEQ A Fidelity Nasdaq Composite Index Tracking Stock 0.08
    HKND C Humankind US Stock ETF 0.08
    FTLS A First Trust Long/Short Equity 0.08
    TSPA A T. Rowe Price U.S. Equity Research ETF 0.08
    DFAS B Dimensional U.S. Small Cap ETF 0.08
    AVSC B Avantis U.S. Small Cap Equity ETF 0.08
    IWS A iShares Russell Mid-cap Value ETF 0.07
    JMEE B JPMorgan Market Expansion Enhanced Equity ETF 0.07
    PTL B Northern Lights Fund Trust IV Inspire 500 ETF 0.06
    AVDE D Avantis International Equity ETF 0.06
    KOMP B SPDR Kensho New Economies Composite ETF 0.06
    ESGV A Vanguard ESG U.S. Stock ETF 0.05
    HDG A ProShares Hedge Replication ETF 0.05
    EZM B WisdomTree MidCap Earnings Fund 0.05
    FYX B First Trust Small Cap Core AlphaDEX 0.05
    APIE D Trust for Professional Managers ActivePassive International Equity ETF 0.05
    STXG A Strive 1000 Growth ETF 0.05
    NBCR A Neuberger Berman Core Equity ETF 0.05
    TILT B FlexShares Mornigstar US Market Factors Tilt Index Fund ETF 0.05
    JCTR A JPMorgan Carbon Transition U.S. Equity ETF 0.04
    VTI A Vanguard Total Stock Market ETF 0.04
    VTHR A Vanguard Russell 3000 ETF 0.04
    FNDA B Schwab Fundamental U.S. Small Company Index ETF 0.04
    BBSC B JPMorgan BetaBuilders U.S. Small Cap Equity ETF 0.04
    JSTC B Adasina Social Justice All Cap Global ETF 0.04
    AVSD D Avantis Responsible International Equity ETF 0.04
    SCHK A Schwab 1000 ETF 0.03
    AVLC A Avantis U.S. Large Cap Equity ETF 0.03
    SCHG A Schwab U.S. Large-Cap Growth ETF 0.03
    AVSU B Avantis Responsible U.S. Equity ETF 0.03
    SCHB A Schwab U.S. Broad Market ETF 0.03
    VONV A Vanguard Russell 1000 Value ETF 0.03
    RWK B RevenueShares Mid Cap 0.03
    GUSA A Goldman Sachs MarketBeta U.S. 1000 Equity ETF 0.03
    DCOR A Dimensional US Core Equity 1 ETF 0.03
    DFAC B Dimensional U.S. Core Equity 2 ETF 0.03
    IUSG A iShares Core U.S. Growth ETF 0.03
    ITOT A iShares Core S&P Total U.S. Stock Market ETF 0.03
    VT B Vanguard Total World Stock Index ETF 0.03
    GVUS A Goldman Sachs MarketBeta Russell 1000 Value Equity ETF 0.02
    DFSU B Dimensional US Sustainability Core 1 ETF 0.02
    VONG A Vanguard Russell 1000 Growth ETF 0.02
    SPTM A SPDR Portfolio Total Stock Market ETF 0.02
    CVLC A Calvert US Large-Cap Core Responsible Index ETF 0.02
    IWB A iShares Russell 1000 ETF 0.02
    JHML A John Hancock Multifactor Large Cap ETF 0.02
    IWF B iShares Russell 1000 Growth ETF 0.02
    DFAU A Dimensional US Core Equity Market ETF 0.02
    DFUS A Dimensional U.S. Equity ETF 0.02
    IUSV A iShares Core U.S. Vaue ETF 0.02
    IWD A iShares Russell 1000 Value ETF 0.02
    DFUV B Dimensional US Marketwide Value ETF 0.02
    JUST A Goldman Sachs JUST U.S. Large Cap Equity ETF 0.02
    MMTM B SPDR S&P 1500 Momentum Tilt ETF 0.02
    GGUS A Goldman Sachs MarketBeta Russell 1000 Growth Equity ETF 0.02
    VONE A Vanguard Russell 1000 ETF 0.02
    FAD A First Trust MuFirst Trust Multi CG AlphaDEX 0.02
    IYY A iShares Dow Jones U.S. ETF 0.02
    SCHX A Schwab U.S. Large-Cap ETF 0.01
    VLU A SPDR S&P 1500 Value Tilt ETF 0.01
    DFIC D Dimensional International Core Equity 2 ETF 0.01
    DEUS B Deutsche X-trackers Russell 1000 Enhanced Beta ETF 0.01
    AVUS A Avantis U.S. Equity ETF 0.01
    RECS A Columbia Research Enhanced Core ETF 0.01
    AVMC A Avantis U.S. Mid Cap Equity ETF 0.0
    SPGM B SPDR Portfolio MSCI Global Stock Market ETF 0.0
    DFIV D Dimensional International Value ETF 0.0
    FNDB B Schwab Fundamental U.S. Broad Market Index ETF 0.0
    STXV A Strive 1000 Value ETF 0.0
    REVS A Columbia Research Enhanced Value ETF 0.0
    ONEO A SPDR Russell 1000 Momentum Focus ETF 0.0
    DFAT B Dimensional U.S. Targeted Value ETF 0.0
    BTAL C QuantShares U.S. Market Neutral Anti Beta Fund ETF -0.45
    CLSE A Convergence Long/Short Equity ETF -0.54
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