Endocrine disease is a disorder of the endocrine system, which is a network of glands that produce hormones that regulate metabolism, growth and development, tissue function, sexual function, reproduction, sleep, and mood, among other things. Endocrine diseases can be caused by a variety of factors, including genetic mutations, autoimmune diseases, infections, tumors, and environmental factors. Common endocrine diseases include diabetes, thyroid disorders, and adrenal disorders.