The economy of Louisville is largely based on the city's location at the crossroads of three major interstate highways. Louisville is home to several major companies, including Brown-Forman, Humana, Yum! Brands, and Papa John's International. The city is also a major center for the health care and medical sciences industries, with several major hospitals and research centers located in the area. Louisville is also home to a thriving manufacturing sector, with several major automotive and aerospace companies located in the city.