SBIO vs. FPXE ETF Comparison

Comparison of ALPS Medical Breakthroughs ETF (SBIO) to First Trust IPOX Europe Equity Opportunities ETF (FPXE)
SBIO

ALPS Medical Breakthroughs ETF

SBIO Description

The investment seeks investment results that correspond (before fees and expenses) generally to the performance of its underlying index, the Poliwogg Medical Breakthroughs IndexSM. The fund employs a "passive management" - or indexing - investment approach designed to track the performance of the underlying index. It will normally invest at least 80% of its net assets in securities that comprise the underlying index. The underlying index is comprised of small- and mid-cap stocks of biotechnology and pharmaceutical companies that have one or more drugs in either Phase II or Phase III U.S. Food and Drug Administration clinical trials. It is non-diversified.

Grade (RS Rating)

Last Trade

$38.26

Average Daily Volume

6,572

Number of Holdings *

83

* may have additional holdings in another (foreign) market
FPXE

First Trust IPOX Europe Equity Opportunities ETF

FPXE Description The First Trust IPOX® Europe Equity Opportunities ETF (the "Fund") seeks investment results that correspond generally to the price and yield (before the Fund's fees and expenses) of an equity index called the IPOX® 100 Europe Index (the "Index"). The Fund will normally invest at least 90% of its net assets (including investment borrowings) in common stocks and/or depositary receipts that comprise the Index. The Fund, using an indexing investment approach, attempts to replicate, before fees and expenses, the performance of the Index. The Fund's investment advisor seeks a correlation of 0.95 or better (before fees and expenses) between the Fund's performance and the performance of the Index; a figure of 1.00 would represent perfect correlation. The Index is owned, developed, maintained and sponsored by IPOX® Schuster LLC (the "Index Provider").

Grade (RS Rating)

Last Trade

$26.03

Average Daily Volume

445

Number of Holdings *

18

* may have additional holdings in another (foreign) market
Performance
Period SBIO FPXE
30 Days 1.91% -0.82%
60 Days 2.27% -2.17%
90 Days 7.65% 7.05%
12 Months 52.91% 31.09%
2 Overlapping Holdings
Symbol Grade Weight in SBIO Weight in FPXE Overlap
MRUS C 2.38% 0.8% 0.8%
VRNA A 1.83% 0.24% 0.24%
SBIO Overweight 81 Positions Relative to FPXE
Symbol Grade Weight
RNA C 3.38%
KRYS C 3.33%
CORT B 3.2%
CRNX B 3.04%
ACLX B 3.02%
IMVT F 2.93%
ALKS F 2.88%
DNLI C 2.39%
FOLD B 2.27%
ZLAB B 2.11%
PTCT B 2.05%
XENE C 2.03%
EWTX B 2.03%
PTGX B 1.77%
CGON F 1.67%
AGIO B 1.65%
IDYA F 1.61%
ACAD F 1.57%
GERN C 1.55%
VERA A 1.5%
KROS A 1.41%
VCEL D 1.35%
LBPH A 1.34%
AKRO A 1.3%
MIRM B 1.25%
GLPG F 1.25%
ARVN C 1.22%
CLDX F 1.21%
MNKD A 1.14%
BCRX A 1.1%
SNDX F 1.07%
IMCR F 1.06%
RCUS F 1.04%
NTLA F 1.03%
TARS A 0.97%
VRDN B 0.93%
SPRY B 0.92%
IRON D 0.9%
KURA F 0.89%
COGT B 0.89%
XNCR A 0.87%
DAWN A 0.85%
PHVS A 0.77%
APLT A 0.71%
AUPH A 0.65%
ANAB F 0.59%
PRTA F 0.58%
LQDA C 0.58%
PLRX A 0.56%
ETNB D 0.54%
REPL B 0.53%
ERAS C 0.48%
ANNX B 0.47%
OLMA F 0.46%
MLYS B 0.44%
YMAB A 0.43%
IRWD F 0.4%
CELC D 0.4%
ALLO D 0.38%
SVRA D 0.37%
FLGT C 0.37%
URGN F 0.35%
ARCT F 0.35%
AURA B 0.34%
FULC F 0.34%
ALT D 0.32%
ALEC D 0.3%
CMPS F 0.29%
AVXL A 0.29%
TBPH C 0.28%
FDMT F 0.27%
GHRS D 0.25%
ALDX D 0.21%
ACIU F 0.2%
INZY F 0.19%
STRO D 0.19%
ITOS F 0.19%
ENTA D 0.17%
VNDA D 0.17%
ZNTL D 0.15%
HLVX C 0.06%
SBIO Underweight 16 Positions Relative to FPXE
Symbol Grade Weight
ARM B -6.99%
MNDY A -4.62%
SPOT A -4.33%
GEN A -3.7%
ONON D -3.6%
CLBT A -1.69%
TEVA A -0.93%
CNTA A -0.59%
JHG A -0.58%
BIRK F -0.41%
SPNT D -0.41%
IMTX F -0.32%
SRAD B -0.17%
GENI D -0.15%
OSW A -0.08%
DOLE C -0.07%
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