Flupirtine is an aminopyridine that functions as a centrally acting non-opioid analgesic that was originally used as an analgesic for acute and chronic pain but in 2013 due to issues with liver toxicity, the European Medicines Agency restricted its use to acute pain, for no more than two weeks, and only for people who cannot use other painkillers. In February 2018 EMA's Pharmacovigilance Risk Assessment Committee has recommended that, the marketing authorisation for flupirtine be withdrawn. This recommendation was based on the finding that the restrictions introduced in 2013 have not been sufficiently followed in clinical practice, and cases of serious liver injury still occurred including liver failure. As of March 2018 the marketing authorisations of flupirtine-containing medicines are not yet withdrawn and a final decision is pending.Flupirtine is a selective neuronal potassium channel opener (SNEPCO) that also has NMDA receptor antagonist and GABAA receptor modulatory properties.It first became available in Europe in 1984 under the brand name Katadolon and after it went off patent many generic brands were introduced.